Medicinal plastic bottles and membranes are not suitable for long-term placement of drugs

An old friend who hasn’t seen him for many years came to see him uncle. Uncle Ho was very happy. Not a few minutes after meeting and sat down, and suddenly he was holding his chest in pain. The daughter knew that his father's angina pectoris had returned. He immediately plucked a nitroglycerin tablet from his pocket and gave it under his tongue. After a few minutes, the pain did not abate, and it was still ineffective to convince one another. Looking at the painful expression of Uncle He, everyone panicked and quickly rushed to hospital for emergency treatment. Afterwards, Uncle Ho feels puzzled. He usually takes a good medicine and how this time will not work. He took the medicine and asked the doctor. The doctor found that the tablets were loose and sticky. The tablets were filled with plastic film bags for monosodium glutamate. The nitroglycerin tablets were usually packed in brown glass. His daughter explained that in order to facilitate medication and carry it one month ago, the drug delivery tablets were replaced by simple packaging. . This is the case, the doctor figured out that it is likely that the plastic bags cause trouble. Plastic film bags do not block light and do not avoid heat and moisture. Plastics have an adsorption effect on nitroglycerin. As time goes by, nitroglycerin tablets will fail and almost cause a big mistake.

In general, in vivo drug interactions often lead to enhanced toxicity or reduced efficacy or even failure of certain drugs. The interaction of the drug with certain substances in vitro, such as packaging, results in a decrease in the bioavailability of the drug or a decrease in the drug. effect. Some plastic products have obvious adsorption effects on certain drugs, thereby reducing the effective concentration of drugs, which has been confirmed in clinical practice. It is known that plastics can produce clinically significant adsorption effects for the following drugs: diazepam, insulin, diazepam, nitroglycerin, isosorbide, acetate, warfarin sodium, azine hydrochloride and thiopental, There are also some antihistamines and phenothiazines. The nitroglycerin adsorption rate is as high as 80%. It has been reported that some drugs can also react with syringes. For example, doxorubicin hydrochloride reacts with injection needles to precipitate or discolor. BEP-epoxy and amine benzoine can react with disposable plastic syringes, so it should be based on Injections are syringes of nature in order to avoid adverse interactions. There are also some Chinese herbal medicines that are packed in plastic bottles that are too long to spoil and deteriorate.

At present, most commercially available plastic medicine bottles are high-density polyethylene plastic products, which have relatively large air permeability, moisture permeability, and light transmittance, so the medicine in the bottle cannot be completely isolated from the outside air, moisture, light source, and heat source. As a result, drugs are susceptible to these factors and are gradually destroyed or spoiled. If people take this medicine, it will not only be useless, but will aggravate the condition. The use of neutral glass bottles for liquids, there is no rancidity, precipitation, moisture and loss of liquid capacity, especially brown glass bottles, has a good light protection effect, especially suitable for containing drugs easily decomposed due to light (such as phenol , Adrenalin, quinolone antibiotics, vitamins A, D, B12, reserpine, iodoform, hydrogen peroxide, etc.). Propolis solvents generally contain alcohol, which easily reacts with plastics to generate harmful substances that are detrimental to human health. It is best to use glass bottles. In the wet season, drugs are susceptible to moisture deterioration. Therefore, after the drug is used, the original packaging should be restored as much as possible to keep the drugs in a sealed state. Avoid using paper bags, paper boxes, plastic bags and other non-moisture-proof packaging materials.

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